Abstract: Blood perfusion and interstitial fluid transport in metastatic tumor microcirculation based on microvasculature response to angiostatin's inhibitory effect are investigated.Microvascular network model contains inhibitory effect of angiostatin,chemotaxis response of tumor angiogenic factors and random motility of endothelial cells.Blood flow,interstitial fluid transport and transvascular flow are described by extended Poiseuille's,Darcy's and Starling's law,respectively.It shows that angiostatin can decrease branching,anastomosis and proliferation of capillary sprouts and inhibit growth of a capillary network in metastatic tumor;Angiostatin can improve capacity of blood perfusion and material exchange within metastatic tumor microenvironment;Furthermore,angiostatin can increase convective flow out of vasculature and result in reduced difficulty of drug delivery and penetration within a metastatic tumor,which agree with experimental observed facts.It may provide theoretical references and foundation understandings for further clinical anti-angiogenic cancer therapy.

Key words: angiostatin, inhibitory effect, metastatic tumor, blood perfusion, interstitial fluid transport