A PML model based on fixed surface roughness is used in simulation of surface roughness effect on flow in mini-channels. Compared with 3-D simulation, results of pressure drop agree well. With PML model and 3-D model we simulate different flow rates and roughness, it shows that surface roughness results in speed linear flow substrate. Pressure drop and relative roughness follow a secondary power relation as Re number is fixed. Pressure drop increased linearly with Re number as roughness elements is equal.

A non-Newtonian shear-thinning model is shown and applied to multiphase flow simulation in 3-D micro-tubes.The model is validated by comparing simulation and experimental results.Velocity simulated agrees well with experimental data and shows F-L effect in microscale hemodynamics.To investigate non-membrane hemodialysis,we simulate hemodialysis in a T-shape mixer.Simulation indicates that components with larger mass diffusion coefficient pervade sufficiently and they can be separated from other components.