With dynamic coupling model of fractured anisotropic full-tensor permeability, a complete three-dimensional three-phase fluid-solid coupling model for anisotropic ultra-low permeability reservoir is established. Using modular explicit coupling iteration, we establish a fluid & solid coupling seepage numerical simulation method considering fracture deformation and corresponding coupling program. It shows that for fractured reservoir, with change of reservoir pressure in process of mining, rock deformation and anisotropy of reservoir medium strain can make various deformation degree in multiple sets of cracks, cause nonlinear change of fracture permeability, which makes principal value of reservoir fracture permeability tensor rotating, changing flow direction, affecting reservoir development effect.