The numerical simulations is carried out on interface with large deformation induced by interaction between a moving shock and Helium bubbles.The high performance of the level set method coupling with GFM (ghost fluid method) method was demonstrated. Upwind TVD scheme was used to solve Eulerian equation for flowfield,and 5th WENO scheme was used to solve level set equation for fluid interfaces' tracking.GFM was applied to deal with the interface boundary.Example in Ref.[1] was used to validate our codes.Finally,the results were obtained on moving shock interacting with helium bubbles including the bubbles evolution.The results indicate that multi-interface can be perfectly tracked by extension of level set equation for multi-fluid interfaces.