We investigate collision characteristics of micro-sized particles (diameter less than 100 microns) via numerical simulations and experiments. Discrete element method (DEM) simulations, based on improved hard-sphere model, are performed to explore effect of initial velocity, surface energy, size, mass concentration, and wind speed on cohesive collisions and non-cohesive collisions between micro-sized particles. Aggregation and settlement process are considered as well. It is found that simulated cohesive collision rate agrees with experimental results of self-settlement of micro-sized particles.