Angiostatin抑制转移性肿瘤血液灌注和间质液输运的数值模拟

计算物理 ›› 2013, Vol. 30 ›› Issue (4): 527-533.

Angiostatin抑制转移性肿瘤血液灌注和间质液输运的数值模拟

赵改平¹, 方新果¹, 陈二云², 俞晓立³

1. 上海理工大学医疗器械与食品学院, 上海 200093;
2. 上海理工大学能源与动力工程学院, 上海 200093;
3. 复旦大学附属肿瘤医院, 上海 200032

收稿日期:2012-09-26 修回日期:2013-01-21 出版日期:2013-07-25 发布日期:2013-07-25
作者简介:赵改平(1975-),female,PhD,major in biological mechanics,E-mail:zgp_06@126.com
基金资助:
Supported by the National Natural Science Foundation of China(51106099);Innovation Program of Shanghai Municipal Education Commission(12YZ109);National Natural Science Foundation of China Cultivate Project(12XGQ04)

Numerical Study of Inhibitory Effect of Angiostatin in Blood Perfusion and Interstitial Transport in Metastatic Tumor

ZHAO Gaiping¹, FANG Xinguo¹, CHEN Eryun², YU Xiaoli³

1. School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China;
2. School of Energy and Power Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China;
3. Fudan University Shanghai Cancer Center, Shanghai 200032, China

Received:2012-09-26 Revised:2013-01-21 Online:2013-07-25 Published:2013-07-25
Supported by:
Supported by the National Natural Science Foundation of China(51106099);Innovation Program of Shanghai Municipal Education Commission(12YZ109);National Natural Science Foundation of China Cultivate Project(12XGQ04)

摘要/Abstract

摘要： 数值研究抗血管生成因子Angiostatin对转移性肿瘤微循环内血液灌注和间质液输运的抑制效应.肿瘤微血管网生成数学模型包括angiostatin的抑制效应、促血管生成因子的趋化效应和内皮细胞自身的扩散效应,血液灌注、间质液输运和跨壁流体交换分别采用Poiseuille、Darcy和Starling定律来描述.结果表明:angiostatin能抑制转移性肿瘤内外微血管网的生长速率、毛细血管芽的分叉、融合与增殖;进一步angiostatin可改善转移性肿瘤微环境内血液灌注和间质液输运的特性,从而增加微血管内外流体对流和物质交换的能力,降低肿瘤内药物输运困难,结果与实验相符,可为临床抗血管生成治疗肿瘤提供有益信息.

关键词: angiostatin, 抑制效应, 转移性肿瘤, 血液灌注, 间质液输运

Abstract: Blood perfusion and interstitial fluid transport in metastatic tumor microcirculation based on microvasculature response to angiostatin's inhibitory effect are investigated.Microvascular network model contains inhibitory effect of angiostatin,chemotaxis response of tumor angiogenic factors and random motility of endothelial cells.Blood flow,interstitial fluid transport and transvascular flow are described by extended Poiseuille's,Darcy's and Starling's law,respectively.It shows that angiostatin can decrease branching,anastomosis and proliferation of capillary sprouts and inhibit growth of a capillary network in metastatic tumor;Angiostatin can improve capacity of blood perfusion and material exchange within metastatic tumor microenvironment;Furthermore,angiostatin can increase convective flow out of vasculature and result in reduced difficulty of drug delivery and penetration within a metastatic tumor,which agree with experimental observed facts.It may provide theoretical references and foundation understandings for further clinical anti-angiogenic cancer therapy.

Key words: angiostatin, inhibitory effect, metastatic tumor, blood perfusion, interstitial fluid transport

中图分类号:

赵改平, 方新果, 陈二云, 俞晓立. Angiostatin抑制转移性肿瘤血液灌注和间质液输运的数值模拟[J]. 计算物理, 2013, 30(4): 527-533.

ZHAO Gaiping, FANG Xinguo, CHEN Eryun, YU Xiaoli. Numerical Study of Inhibitory Effect of Angiostatin in Blood Perfusion and Interstitial Transport in Metastatic Tumor[J]. CHINESE JOURNAL OF COMPUTATIONAL PHYSICS, 2013, 30(4): 527-533.