Study on Reentrant Arrhythmia Caused by Weak Coupling

doi:10.19596/j.cnki.1001-246x.8761

Abstract

Abstract:

The Luo Rudy phase I heart model is used in this paper to study the propagation of waves generated by point wave sources in one- and two-dimensional weakly coupled myocardial tissues. It is observed that the weak coupling can lead to the reduction of the wave propagation speed. When there is a large coupling intensity gradient in the myocardial tissue, weak coupling can lead to the frustration of wave propagation and early afterdepolarization showed by cardiomyocytes. When the coupling intensity between cardiomyocytes is low enough, circular motion of wave and complex wave propagation can be observed in myocardial tissues. In addition, we also study the propagation of planar wave in two-dimensional weakly coupled myocardial tissues by constructing two different two-dimensional myocardial tissues with different coupling structures. We find that spiral waves can be spontaneously generated when plane wave propagates in the two myocardial tissues. Increasing the coupling intensity between cells can effectively prevent the circus movement of wave and the spontaneous generation of spiral wave. The physical mechanism of the above phenomenon is analyzed in this paper.

Key words: weak coupling, myocardial ischemia, spiral wave, arrhythmia

CLC Number:

O411.3

Zhijie WEI, Yuxiang MO, Rongmei LIN, Xiaoke LAN, Guoning TANG. Study on Reentrant Arrhythmia Caused by Weak Coupling[J]. Chinese Journal of Computational Physics, 2024, 41(5): 670-679.

Figures/Tables 8

Fig.1 Spatiotemporal patterns of membrane potential at different coupling intensities (a) D1=0.000 2 cm2 ·ms-1; (b) D1=0.000 5 cm2 ·ms-1

Fig.2 Evolution of membrane potential of cardiomyocytes on both sides of the boundary between weak and strong coupling regions at different coupling intensities (a) D1=0.000 2 cm2 ·ms-1; (b) D1=0.000 5 cm2 ·ms-1

Fig.3 Spatiotemporal patterns of membrane potential of cardiomyocytes in (a) the first row and (b) the second row at Dx=0.000 5 cm2 ·ms-1 and Dy=0.000 105 cm2 ·ms-1

Fig.4 Evolution of cardiomyocytes membrane potential with time at different sites of Dx=0.000 5 cm2 ·ms-1 and Dy=0.000 105 cm2 ·ms-1 (a) i=150; (b) i=75

Fig.5 Patterns of membrane potential at different time points with Dy=0.000 5 cm2 ·ms-1 and Dy=0.000 110 cm2 ·ms-1 (a) t=80 ms; (b) t=145 ms; (c) t=155 ms; (d) t=180 ms; (e) t=200 ms; (f) t=210 ms; (g) t =220 ms; (h) t=250 ms; (i) t=340 ms; (j) t=380 ms; (k) t=420 ms; (l) t=500 ms; (m) t=509 ms; (n) t=540 ms; (o) t=610 ms; (p) t=700 ms

Fig.6 Patterns of membrane potential at different time points with D2=0.000 25 cm2 ·ms-1 (The region enclosed by the gray dotted line in Fig.(a) is the normal coupling region. The rest is the weak coupling region.) (a) t=100 ms; (b) t=200 ms; (c) t=240 ms; (d) t=300 ms; (e) t=440 ms; (f) t=520 ms; (g) t=570 ms; (h) t=750 ms; (i) t=800 ms

Fig.7 Patterns of membrane potential in the first layer myocardial tissue at different time points (The gray-white dotted ine and the dotted line box display the interlayer coupling regions, corresponding to interlayer coupling intensities are D12L=0.000 4 cm2 ·ms-1 and D12R=0.001 cm2 ·ms-1, respectively.) (a) t=38 ms; (b) t=98 ms; (c) t=156 ms; (d) t=200 ms; (e) t=230 ms; (f) t=263 ms; (g) t=340 ms; (h) t=400 ms; (i) t=510 ms

Fig.8 Patterns of membrane potential in the second layer myocardial tissue at different time points (The gray-white dotted line and the dotted line box display the interlayer coupling regions, corresponding to interlayer coupling intensities are D12L=0.0004 cm2 ·ms-1 and D12R=0.001 cm2 ·ms-1, respectively.) (a) t=38 ms; (b) t=98 ms; (c) t=156 ms; (d) t=200 ms; (e) t=230 ms; (f) t=263 ms; (g) t =340 ms; (h) t=400 ms; (i) t=510 ms

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